Mandisa is a feminine given name of South African origin, meaning "sweet". Notable people with the given name include:
Mandisa Hundley (1976–2024), known mononymously as Mandisa, American gospel singer Mandisa Makesini ( 2014–present), South African politician Mandisa Mashego (born 1973), South African politician and feminist Mandisa Maya (born 1964), South African judge Mandisa Mfeka ( 2008–present), South African pilot Mandisa Monakali (died 2024), South African public speaker, lobbyist, educator, social worker and community organizer Mandisa Stevenson (born 1982), American basketball player Mandisa Thomas (born 1976), American atheist activist Mandisa Williams (born 1984), South African rugby union player