The Women's 100 metre individual medley competition of the 2022 FINA World Swimming Championships (25 m) was held on 15 and 16 December 2022.

Records Prior to the competition, the existing world and championship records were as follows.

Results Heats The heats were started on 15 December at 12:02.

Rank Heat Lane Name Nationality Time Notes 1 3 4 Louise Hansson 57.98 Q 2 2 4 Marrit Steenbergen 58.87 Q 3 4 3 Helena Gasson 58.92 Q 4 4 5 Mary-Sophie Harvey 58.93 Q 5 4 4 Béryl Gastaldello 59.19 Q 5 2 5 Costanza Cocconcelli 59.19 Q 7 2 3 Lena Kreundl 59.29 Q 8 2 6 Rebecca Meder 59.38 Q, AF 9 3 1 Neža Klančar 59.42 Q, NR 10 3 3 Yui Ohashi 59.49 Q 10 3 5 Sydney Pickrem 59.49 Q 12 4 6 Emelie Fast 59.53 Q 13 2 2 Tamara Potocká 59.69 Q, NR 14 3 2 África Zamorano 59.99 Q, NR 15 3 6 Diana Petkova Q 16 2 7 Kayla Hardy Q 17 3 7 McKenna DeBever NR 18 4 7 Stefanía Gómez 19 2 1 Maria Romanjuk 20 4 1 Stephanie Balduccini 21 1 4 Kristen Romano NR 22 4 8 Chloe Isleta 23 1 7 Chang Yujuan 24 1 1 Jayla Pina 25 3 8 Arina Baikova 26 2 8 Kirsten Fisher-Marsters 27 1 3 Mia Lee 28 1 2 Jennifer Harding-Marlin 29 1 6 Kestra Kihleng 30 1 5 Galyah Mikel 4 2 Kristýna Horská

Semifinals The semifinals were started on 15 December at 20:57.

Rank Heat Lane Name Nationality Time Notes 1 1 4 Marrit Steenbergen 57.65 Q 2 2 4 Louise Hansson 58.05 Q 3 2 7 Sydney Pickrem 58.54 Q 4 1 3 Béryl Gastaldello 58.61 Q 5 1 6 Rebecca Meder 58.98 Q, AF 6 2 6 Lena Kreundl 59.04 Q, NR 7 1 5 Mary-Sophie Harvey 59.13 Q 8 2 5 Helena Gasson 59.15 Q 9 2 2 Neža Klančar 59.27 NR 10 2 3 Costanza Cocconcelli 59.34 11 1 2 Yui Ohashi 59.45 11 2 8 Diana Petkova 59.45 13 2 1 Tamara Potocká 59.55 NR 14 1 7 Emelie Fast 59.61 15 1 8 Kayla Hardy 59.75 1 1África Zamorano

Final The final was held on 16 December at 20:56.

Rank Lane Name Nationality Time Notes 4 Marrit Steenbergen 57.53 NR 6 Béryl Gastaldello 57.63 5 Louise Hansson 57.68 4 3 Sydney Pickrem 58.26 5 8 Helena Gasson 58.40 NR 6 2 Rebecca Meder 58.46 AF 7 7 Lena Kreundl 58.79 NR 8 1 Mary-Sophie Harvey 59.11

References