Hypostomus pospisili is a species of catfish in the family Loricariidae. It is native to South America, where it is known only from Venezuela. The species is believed to be a facultative air-breather. A 2003 taxonomic review conducted by Jonathan W. Armbruster of Auburn University listed Hypostomus pospisili as a synonym of Hypostomus hondae,Armbruster, J.W. (2003). The species of the Hypostomus cochliodon group (Siluriformes: Loricariidae). Zootaxa, 249, 1-60. although multiple sources recognize H. pospisili as a distinct species.
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