Mary Osborn (born 1940) is an English cell biologist.

Mary Osborn or Osborne may also refer to:

Mary Jane Osborn (1927–2019), American biochemist and molecular biologist Mary Osborne (1921–1992), American jazz guitarist and guitar manufacturer Mary Pope Osborne (born 1949), American author Mary Osborne, Duchess of Leeds (1723–1764), noblewoman Mary Osborn (murderer) (c. 1773–1801), the first woman to be executed in Upper Canada

See also Mary Osbourne (born 1982), winner of the MTV reality television show Surf Girls Emily Mary Osborn (1828–1925), English painter of the Victorian era Mary Osburn Adkinson (1843–1918), née Osburn, American social reformer active in the temperance movement Mary Osborn Douthit (1850–1908), early white Oregon settler, teacher, and advocate of woman suffrage