The canton of Pouilly-sur-Loire is an administrative division of the Nièvre department, central France. Its borders were modified at the French canton reorganisation which came into effect in March 2015. Its seat is in Pouilly-sur-Loire.

It consists of the following communes:

Annay Arquian Bitry Bouhy Bulcy Cessy-les-Bois Châteauneuf-Val-de-Bargis Ciez Colméry Couloutre Dampierre-sous-Bouhy Donzy Garchy Menestreau Mesves-sur-Loire Neuvy-sur-Loire Perroy Pouilly-sur-Loire Saint-Amand-en-Puisaye Saint-Andelain Sainte-Colombe-des-Bois Saint-Laurent-l'Abbaye Saint-Malo-en-Donziois Saint-Martin-sur-Nohain Saint-Quentin-sur-Nohain Saint-Vérain Suilly-la-Tour Tracy-sur-Loire Vielmanay

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