2,3,4-Trimethoxyamphetamine (2,3,4-TMA), also known as TMA-3 or as α-methylisomescaline, is a putative psychedelic drug of the phenethylamine and amphetamine families. https://erowid.org/library/books_online/pihkal/pihkal159.shtml It is one of the possible positional isomers of trimethoxyamphetamine and is a positional isomer of 3,4,5-trimethoxyamphetamine (TMA or TMA-1).
Use and effects In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2,3,4-TMA's dose as greater than 100mg orally and its duration as unknown. The drug produced no effects whatsoever at a dose of 100mg in three separate individuals. Higher doses were not tested, but 2,3,4-TMA could possibly be active at higher doses.
Interactions
Pharmacology Pharmacodynamics 2,3,4-TMA shows affinity for serotonin receptors. It substituted for DOM in rodent drug discrimination tests.
Chemistry Synthesis The chemical synthesis of 2,3,4-TMA has been described.
History 2,3,4-TMA was first described in the scientific literature by Alexander Shulgin in 1964. Subsequently, it was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).
Society and culture Legal status Canada 2,3,4-TMA is a controlled substance in Canada under phenethylamine blanket-ban language.
United States As a positional isomer of 3,4,5-trimethoxyamphetamine (TMA), 2,3,4-TMA is a Schedule I controlled substance in the United States.
See also Trimethoxyamphetamine Substituted methoxyphenethylamine Isomescaline (2,3,4-TMPEA; TMPEA-4)
References
External links TMA-3 - Isomer Design TMA-3 - PiHKAL - Erowid TMA-3 - PiHKAL - Isomer Design TMA-3 - The Shulgin Index