Mad cow is a common term for bovine spongiform encephalopathy, a neurodegenerative disease of cattle.
Mad cow may also refer to:
Arts Branded (2012 film), also known as The Mad Cow The Mad Cows, a British band Mad Cow Theatre, a Florida theatre company "Mad Cow", a 2012 single by Hank Williams III Mad Cows, a 1996 novel by Kathy Lette Mad Cows, a 1999 film based on the 1996 novel, starring Anna Friel "Mad Cow Disease", a song by Goodbye Mr Mackenzie on the 1990 single "Blacker Than Black"
Other uses Mad Cow-Girl (1961–2010), British nurse and politician Red Cow interchange, nicknamed Mad Cow