6'''-hydroxyneomycin C oxidase (, neoG (gene)) is an enzyme with systematic name 6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase. It catalyses the oxidation of 6"'-hydroxyneomycin C to 6"'-oxoneomycin C using molecular oxygen as oxidant and giving hydrogen peroxide as byproduct:
This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family.
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