Francis Clerke may refer to:
Francis Clerke (lawyer) (fl. 1594), English lawyer Francis Clerke (politician, died 1686) (c. 1624–1686), English politician, MP for Rochester Francis Clerke (politician, died 1715) (c. 1655–1715), English politician, MP for Oxfordshire Francis Clerke (politician, died 1691) (c. 1665–1691), English politician, MP for Rochester Sir Francis Clerke, 6th Baronet (1682–1769), of the Clerke baronets, Gentleman Usher Sir Francis Clerke, 7th Baronet (1748–1778), aide-de-camp to General John Burgoyne, killed at Saratoga
See also Francis Clark (disambiguation) Frank Clarke (disambiguation)